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Double/Triple Hit Lymphoma
High Grade Aggressive B Cell Lymphomas (Double & Triple-Hit Lymphomas)
The WHO Classification in 2017 classified lymphomas with concurrent rearrangement of MYC, BCL2, and/or BCL6 as high-grade B cell lymphomas with an aggressive clinical course.
Double-hit and triple-hit lymphomas are difficult to classify morphologically without aid of FISH.
The diagnosis is based on interphase FISH for MYC, BCL2, and BCL6.
Abnormal BCL2 FISH
Turnaround Time = 3-5 Days
FISH probes for High Grade B Cell Lymphomas (Double or Triple-Hit)
Swerdlow, S. H., Campo, E., Pileri, S. A., Harris, N. L., Stein, H., Siebert, R., ... & Jaffe, E. S. (2016). The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood, The Journal of the American Society of Hematology, 127(20), 2375-2390.
Bacher, U., Haferlach, T., Alpermann, T., Kern, W., Schnittger, S., & Haferlach, C. (2011). Several lymphoma‐specific genetic events in parallel can be found in mature B‐cell neoplasms. Genes, Chromosomes and Cancer, 50(1), 43-50.