Test #


Test CPT Codes


SARS-CoV-2 Total Nucleocapsid Antibody (IgG, IgA, and IgM) Assay

Test Type

Diagnostic Immunology

Test Disease

COVID-19 Infection

Test Technology


Clinical Utility


Test Specimen

  • Serum/Plasma

Specimen Requirements

  • 3 mL; Minimum : 1 mL

Specimen Collection

  • Serum separator tube (preferred); plasma tube acceptable

About This Test

SARS-CoV-2 total nucleocapsid antibody assay detects total nucleocapsid antibodies to IgM, IgA and IgG in human serum or plasma specimens. The total antibody assay indicates recent or prior infection. It is unknown for how long antibodies persist following infection and if the presence of antibodies confers protective immunity. Antibodies to SARS-CoV-2 are generally detectable in blood several days after initial infection, although the duration of time antibodies are present post-infection is not well characterized. Individuals may have detectable virus present for several weeks following seroconversion.

Test Storage

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Transport Conditions

  • Transport collection Ambient: 48 hours; Refrigerated acceptable; frozen serum or plasma if separated for blood cells

Rejection Criteria

  • Contaminated, heat-inactivated, hemolyzed, or severely lipemic specimens frozen whole blood in sample

Turnaround Time (TAT)

≤2 days

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